Channel Effects

vasodilatory effects barbiturates?

i think barbiturates can have vasodilatory effects and can depress cardiac contractility(pumping strength). Do you have any idea of about the mechanisms for each?

Barbiturates predominantly exert pharmacological effect on GABA receptors. However, it seems that they have a transmembrane (?sodium channel) effect on myocytes. This could account for negative inotropic effect and for vasodilatation.

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